XCHANGE is Xsolis’ annual healthcare leadership conference, bringing together executives from hospitals, health systems, and health plans to explore how artificial intelligence is transforming utilization management, care coordination, revenue cycle operations, and provider-payer collaboration. Each year, executives, clinicians, and operational leaders come together to share best practices, customer success stories, and innovations shaping the future of healthcare.
XCHANGE ’26 was held in San Antonio and featured keynote speakers, customer success stories, executive panels, product innovation sessions, and networking opportunities focused on one central question: How do healthcare organizations move from AI adoption to measurable operational impact?
This recap highlights the biggest themes, customer presentations, and innovations that defined this year’s event — and offers a look at where healthcare AI is headed next.
Every year, XCHANGE brings together healthcare leaders from hospitals and health plans to share ideas, challenge assumptions, and explore new ways to reduce administrative friction across the healthcare system. Designed for executives, clinicians, and operational leaders, the healthcare AI conference focuses on utilization management, revenue cycle performance, care coordination, physician advisor services, health informatics, and responsible AI adoption.
Held May 4–7 in San Antonio, XCHANGE ’26 brought together executives, physician advisors, utilization management leaders, care coordination professionals, revenue cycle experts, and informatics leaders for four days of learning, collaboration, and practical conversations about what comes next for healthcare AI. Attendees also celebrated Cinco de Mayo with an unforgettable evening at the historic Alamo, one of many opportunities to build relationships with peers from across the industry.
While artificial intelligence dominated many industry conferences this year, the conversations at XCHANGE reflected something different: attendees weren’t asking whether AI belongs in healthcare anymore. They were focused on how to operationalize it responsibly, expand its impact, earn clinician trust, and measure meaningful outcomes.
One of the strongest themes throughout the conference was healthcare’s transition from experimentation to execution.
Across keynote presentations, client stories, and panel discussions, several common priorities emerged:
A post-event survey reflected those priorities, with healthcare leaders identifying competing priorities and limited IT bandwidth as the most common barriers to expanding AI initiatives. Organizations also cited operational expansion, governance, and ROI measurement as leading priorities over the next 12–18 months.
Rather than focusing on future possibilities alone, XCHANGE emphasized practical strategies organizations are using today to move AI from isolated projects into sustainable operational capabilities.
One of the defining characteristics of XCHANGE is that many sessions are led by clients sharing their own experiences.
This year’s programming featured organizations including Advocate Health, AnMed, Beacon Health System, Inova Health, MultiCare Health System, Baylor Scott & White Health, Mayo Clinic, Hendrick Health, Kettering Health, Citizens Medical Center, and West Tennessee Healthcare.
Speakers discussed how their organizations are using AI to:
Several organizations also shared measurable outcomes achieved through their Xsolis partnership, including reduced review times, improved throughput, stronger denial management, greater physician advisor efficiency, and significant financial return on investment.
For example, AnMed discussed the Xsolis interventions that led to its 14.6X ROI. Beacon Health System shared how it achieved a 78% overturn rate and accelerated case resolution by combining Dragonfly with Physician Advisory Services. Inova Health System also highlighted how it now completes 80% of initial reviews within the first 24 hours, helping improve efficiency across its utilization management workflows.
While product innovation remained an important part of the event, some of the most engaging discussions centered on organizational change.
Panel discussions explored topics such as:
A recurring message emerged throughout the week: successful AI adoption depends as much on people, governance, and collaboration as it does on technology itself.
Attendees also received an early look at Xsolis’ product roadmap and long-term innovation strategy.
Sessions explored recent advancements including Dragonfly Navigate, GenAI Initial Review, GenAI Clinical Appeal Summary, and the future of Generative Business Intelligence (GenBI), while also introducing attendees to emerging concepts around Agentic AI.
Rather than replacing clinicians, these innovations are designed to reduce repetitive administrative work, surface relevant information faster, and allow healthcare professionals to spend more time applying their expertise where it matters most.
Some of the most valuable conversations happened between sessions. Throughout the week, attendees connected during networking receptions, Champion Sessions, Meet-Ups, and informal discussions with peers facing many of the same operational challenges.
The kickoff party was held this year on Cinco de Mayo at the historic Alamo, where attendees stepped away from presentations to enjoy an unforgettable evening of food, music, and conversation in one of Texas’ most iconic settings. It was a fitting backdrop for strengthening the relationships that continue long after the conference ends.
Whether attendees came to learn from peers, explore the latest innovations, or share their own experiences, XCHANGE ’26 demonstrated what’s possible when healthcare leaders come together around a shared goal: reducing administrative friction so clinicians can focus more on patient care. We look forward to continuing the conversation at XCHANGE ’27.
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